• 文章类型: Journal Article
    目的:前列腺癌根治术后复发疝的发生率较高,因此本文探讨前列腺癌根治术后腹股沟疝的发生率及危险因素。
    方法:回顾性分析湖州市第一人民医院2019年3月至2021年5月251例前列腺癌根治术患者的临床资料。根据腹股沟疝的发生,将受试者分为研究组和对照组,并对各组临床资料进行统计学分析,采用多因素Logistic分析寻找预测腹股沟疝发生的独立影响因素。根据腹股沟疝的发生和时间绘制Kaplan-Meier生存曲线。
    结果:前列腺癌手术后腹股沟疝的总发病率为14.7%(37/251),平均时间为8.58±4.12个月。淋巴结清扫术患者腹股沟疝的平均时间为7.61±4.05(月),未进行淋巴结清扫的患者为9.16±4.15(月),两者比较差异无统计学意义(P>0.05)。腹股沟疝的发病率随年龄的变化无统计学意义,BMI,高血压,糖尿病,PSA,既往腹部手术及手术入路(P>0.05),手术方式和盆腔淋巴结清扫方式差异有统计学意义(P<0.05)。腹股沟疝组盆腔淋巴结清扫的发生率为24.3%(14/57),显著高于对照组11.8%(23/194)。Logistic回归分析显示盆腔淋巴结清扫是前列腺癌术后腹股沟疝的危险因素(OR=0.413,95%Cl:0.196~0.869,P=0.02)。Kaplan-Meier生存曲线显示,盆腔淋巴结清扫组腹股沟疝发生率明显高于对照组(P<0.05)。
    结论:盆腔淋巴结清扫是前列腺癌根治术后腹股沟疝的危险因素。
    OBJECTIVE: The incidence of recurrent hernia after radical resection of prostate cancer is high, so this article discusses the incidence and risk factors of inguinal hernia after radical resection of prostate cancer.
    METHODS: This case control study was conducted in The First People\'s Hospital of Huzhou clinical data of 251 cases underwent radical resection of prostate cancer in this hospital from March 2019 to May 2021 were retrospectively analyzed. According to the occurrence of inguinal hernia, the subjects were divided into study group and control group, and the clinical data of each group were statistically analyzed, Multivariate Logistic analysis was performed to find independent influencing factors for predicting the occurrence of inguinal hernia. The Kaplan-Meier survival curve was drawn according to the occurrence and time of inguinal hernia.
    RESULTS: The overall incidence of inguinal hernia after prostate cancer surgery was 14.7% (37/251), and the mean time was 8.58 ± 4.12 months. The average time of inguinal hernia in patients who received lymph node dissection was 7.61 ± 4.05 (month), and that in patients who did not receive lymph node dissection was 9.16 ± 4.15 (month), and there was no significant difference between them (P > 0.05). There were no statistically significant differences in the incidence of inguinal hernia with age, BMI, hypertension, diabetes, PSA, previous abdominal operations and operative approach (P > 0.05), but there were statistically significant differences with surgical method and pelvic lymph node dissection (P < 0.05). The incidence of pelvic lymph node dissection in the inguinal hernia group was 24.3% (14/57), which was significantly higher than that in the control group 11.8% (23/194). Logistic regression analysis showed that pelvic lymph node dissection was a risk factor for inguinal hernia after prostate cancer surgery (OR = 0.413, 95%Cl: 0.196-0.869, P = 0.02). Kaplan-Meier survival curve showed that the rate of inguinal hernia in the group receiving pelvic lymph node dissection was significantly higher than that in the control group (P < 0.05).
    CONCLUSIONS: Pelvic lymph node dissection is a risk factor for inguinal hernia after radical resection of prostate cancer.
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  • 文章类型: Journal Article
    目的:探讨肾移植术后白内障患者的眼部特征及超声乳化联合人工晶状体(IOL)植入术的结果。
    方法:纳入肾移植术后白内障患者和接受超声乳化联合人工晶状体植入术的对照患者。所有患者均行超声乳化联合人工晶状体植入术。视敏度,眼内压,晶状体不透明度的类型,角膜内皮细胞密度,术前评估眼部生物学参数。视力预后,干眼症,超声乳化术后6个月监测术后并发症。
    结果:我们分析了16例肾移植术后患者的25只眼和21例对照患者的30只眼。肾移植组白内障最常见的类型为后囊膜下,对照组最常见的白内障类型为皮质性白内障。角膜散光的显著差异,白色与白色的比例,两组之间观察角膜曲率测量值。两组术后视力均有明显改善。术后并发症,例如前囊和后囊混浊的程度以及掺钕钇铝石榴石激光囊切开术的发生率,在肾移植组中显著降低。此外,肾移植组有2眼继发性青光眼。
    结论:这项研究表明,肾移植术后的白内障多为后囊下。大多数患者术后视力恢复良好,术后并发症发生率降低。提示超声乳化联合人工晶状体植入术安全有效,为肾移植术后多灶性人工晶状体植入术提供参考。
    OBJECTIVE: To explore ocular characteristics of patients with cataracts after renal transplantation and analyze the results of phacoemulsification combined with intraocular lens (IOL) implantation.
    METHODS: Patients with cataracts after renal transplantation and control patients who underwent phacoemulsification combined with IOL implantation were enrolled. All patients underwent phacoemulsification combined with IOL implantation. Visual acuity, intraocular pressure, type of lens opacity, corneal endothelial cell density, and ocular biological parameters were evaluated before surgery. Visual prognosis, dry eye, and postoperative complications were monitored for 6 months after phacoemulsification.
    RESULTS: We analyzed 25 eyes of 16 patients after renal transplantation and 30 eyes of 21 control patients. The most common type of cataract of renal transplantation group was posterior subcapsular, while the most common type of cataract of control group was cortical. Significant differences in corneal astigmatism, white-to-white ratio, and keratometry values were observed between the groups. The postoperative visual acuity of both groups significantly improved following surgery. Postoperative complications, such as the degree of anterior and posterior capsule opacification and the incidence of a requirement of neodymium-doped yttrium aluminum garnet laser capsulotomy, were significantly lower in the renal transplantation group. Moreover, secondary glaucoma occurred in two eyes in the renal transplantation group.
    CONCLUSIONS: This study showed that cataracts after renal transplantation were mostly posterior subcapsular. Postoperative visual acuity recovered well in most patients, with reduced incidence of postoperative complications. This study suggested that phacoemulsification combined with IOL implantation was safe and effective, providing a reference for multi-focal IOL implantation in kidney transplant recipients.
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  • 文章类型: Journal Article
    目的:经尿道前列腺电切术(TURP)是治疗下尿路症状(LUTS)的前列腺肥大的手术选择之一。在这群老年患者中,伴随的前列腺癌并不少见。然而,之前的TURP导致的前列腺解剖结构纤维化和扭曲可能会阻碍机器人辅助前列腺癌根治术(RARP)的手术疗效.我们的目标是评估功能,和RARP的肿瘤学结果在有和没有以前的TURP患者。
    方法:231名既往TURP患者接受了RARP(TURP组)。这些男性使用临床病理特征与没有进行RARP的先前TURP的男性(对照组)进行了倾向评分匹配。分析了围手术期和术后变量在组间结果上的显著差异。分析的变量包括估计失血量(EBL),手术时间,导管时间,住院时间,术后并发症,手术切缘阳性(PSM)率,癌症状态,生化复发(BCR),效力,效力和节制率。
    结果:TURP组患者在手术安全性措施(包括中位EBL)方面无统计学差异,手术时间,导管时间,住院时间或术后并发症。两组之间在效能率和节制率方面没有显着差异。此外,肿瘤结局没有统计学上的显著差异,包括PSM率(15%对18%,P=0.3)和BCR。
    结论:在TURP后的RARP中,通常会出现明显的手术解剖结构变形。对于经验丰富的团队,该程序是安全的,并且在没有先前TURP的患者中提供与RARP相似的肿瘤控制和功能结果。
    OBJECTIVE: Transurethral resection of the prostate (TURP) is one of the surgical options for treating enlarged prostates with lower urinary symptoms (LUTS). In this older group of patients, concomitant prostate cancer is not uncommon. However, the fibrosis and distortion of the prostate anatomy by prior TURP can potentially hinder surgical efficacy at robotic-assisted radical prostatectomy (RARP). We aim to evaluate functional, and oncologic outcomes of RARP in patients with and without previous TURP.
    METHODS: 231 men with previous TURP underwent RARP (TURP group). These men were propensity score matched using clinicopathological characteristics to men without previous TURP who underwent RARP (Control group). Perioperative and postoperative variables were analysed for significant differences in outcomes between groups. Variables analysed included estimated blood loss (EBL), operative time, catheter time, hospitalization time, postoperative complications, positive surgical margins (PSM) rates, cancer status, biochemical recurrence (BCR), potency, and continence rates.
    RESULTS: Patients in the TURP group showed no statistically significant differences in operative safety measures including median EBL, operative time, catheter time, hospitalization time or postoperative complications. No significant difference between the groups in terms of potency rates and continence rates. Furthermore, there were no statistically significant differences in oncological outcomes, including PSM rates (15% vs 18%, P = 0.3) and BCR.
    CONCLUSIONS: In RARP after TURP there is often noticeable distortion of the surgical anatomy. For an experienced team the procedure is safe and provides similar oncologic control and functional outcomes to RARP in patients without previous TURP.
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  • 文章类型: Journal Article
    背景:胆结石是消化系统最常见的医院诊断,和它的治疗,如果有症状,是腹腔镜胆囊切除术.越来越需要全面确定术后结果和医疗机构的效率。“教科书结果”(TO)表示肿瘤手术中常用的护理质量,通过添加几个术后参数获得,它告知是否获得了完美的结果。这项研究的主要目的是确定胆囊切除术的TO,并了解影响其成就的因素。
    方法:对2018-2020年间接受胆囊切除术的患者进行回顾性观察性单心队列研究。我们将TO定义为符合以下前提的患者:Clavien-Dindo并发症结果:TO的百分比为72%(342/475)(择期手术为82.6%,紧急手术为60.5%)。单因素分析表明,以下因素与实现TO相关:女性,年龄<63岁,ASA风险结论:TO是一种易于执行的医疗保健质量工具,易于解释,并有助于评估医疗保健和比较中心的质量。它不仅适用于肿瘤手术,也适用于胆囊切除术。
    BACKGROUND: Cholelithiasis is the most common hospital diagnosis of the digestive system, and its treatment, if symptomatic, is laparoscopic cholecystectomy. There is a growing need for comprehensive determination of postoperative outcomes and the efficiency of healthcare facilities. The \"textbook outcome\"(TO) indicates the quality of care commonly used in oncological procedures, obtained by adding several postoperative parameters, which informs whether a perfect result has been obtained. The main objective of this study is to determine the TO for cholecystectomy and to see the factors that influence its achievement.
    METHODS: Retrospective observational unicentric cohort study on patients who underwent cholecystectomy between 2018-2020. We defined TO as those patients who met the following premises: Clavien-Dindo complications < III, postsurgical stay less than the 75th percentile (<3 days), and no readmissions or mortality in the first ninety days. Perioperative characteristics were analyzed, and the patients were divided into two groups according to whether or not they achieved TO. We defined criteria for difficult cholecystectomy according to the operative report.
    RESULTS: The percentage of TO was 72% (342/475) (82.6% in elective surgery and 60.5% in urgent surgery). The univariate analysis showed that the following factors are associated with achieving TO: female sex, age <63 years, ASA risk < III, elective surgery, laparoscopic approach, and not difficult cholecystectomy. After multivariate analysis ASA < III (OR 2.39 CI95% 1.37-4.16), elective surgery (OR 2.77 CI95% 1.64-4.67), laparoscopic approach (OR 5.71 CI95% 2.89-11.30) and not to be difficult cholecystectomy (OR 0.42 CI95% 0.259-0.71) remained statistically significant.
    CONCLUSIONS: The TO is a healthcare quality tool that is simple to perform, easily interpretable, and helpful for evaluating quality in healthcare and comparing centers. It applies not only to oncological procedures but also to cholecystectomy.
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  • 文章类型: Journal Article
    目的比较机器人直肠癌手术(RRCS)和腹腔镜直肠癌手术(LRCS)对患者泌尿和性功能的保护作用。我们在PubMed进行了系统的搜索,WebofScience,科克伦图书馆,和Embase用于比较RRCS和LRCS对泌尿功能和性功能的影响的研究。国际前列腺症状评分(IPSS)使用国际勃起功能指数(IIEF-5)和女性性功能指数(FSFI)的五项版本评估患者的排尿功能和性功能。共有13项研究包括1964名患者,包括3项随机对照试验,5项回顾性队列研究,3项前瞻性队列研究,和2项倾向得分匹配的研究。959例患者接受了RRCS,1005例患者接受了LRCS。IPSS评分的统计学分析表明,术后3、6和12个月,RRCS组的排尿功能明显优于LRCS组[平均差异(MD),-1.06,95%CI-1.85至-0.28;和MD,-0.96,95%CI-1.60至-0.32;和MD,-1.09,95%CI-1.72至-0.46]。IIEF-5评分的统计学分析表明,在术后3、6和12个月,RRCS组的男性性功能明显优于LRCS组(MD,1.76,95%CI0.80至2.72;和MD,1.83,95%CI0.34至3.33;和MD,1.05,95%CI0.09至2.01)。FSFI评分的统计分析表明,术后6个月和12个月,RRCS组的女性性功能明显优于LRCS组(MD,2.86;95%CI1.38至4.35;和MD,4.19;95%CI1.85至6.54)。RRCS比LRCS更有利于保持直肠癌患者的泌尿和性功能。
    The purpose of the study was to compare the protective effects of robotic rectal cancer surgery (RRCS) and laparoscopic rectal cancer surgery (LRCS) on urinary and sexual function of patients. We conducted a systematic search in the PubMed, Web of Science, Cochrane Library, and Embase for studies comparing the impact of RRCS and LRCS on urinary function and sexual function. The International Prostate Symptom Score (IPSS), the five-item version of the International Index of Erectile Function (IIEF-5) and the Female Sexual Function Index(FSFI) were used to evaluate the urinary function and sexual function of patients. A total of 13 studies comprising 1964 patients were included in this meta-analysis, including 3 randomized controlled trials, 5 retrospective cohort studies, 3 prospective cohort studies, and 2 propensity score-matched studies. Nine hundred and fifty-nine patients underwent RRCS and 1005 patients underwent LRCS. Statistical analysis of the IPSS scores indicated urinary function was significantly better in the RRCS group than in the LRCS group at 3, 6 and 12 months postoperatively [mean difference (MD), - 1.06, 95% CI - 1.85 to - 0.28; and MD, - 0.96, 95% CI - 1.60 to - 0.32; and MD, - 1.09, 95% CI - 1.72 to - 0.46]. Statistical analysis of the IIEF-5 scores indicated male sexual function was significantly better in the RRCS group than in the LRCS group at 3, 6 and 12 months postoperatively (MD, 1.76, 95% CI 0.80 to 2.72; and MD, 1.83, 95% CI 0.34 to 3.33; and MD, 1.05, 95% CI 0.09 to 2.01). Statistical analysis of the FSFI scores indicated female sexual function was significantly better in the RRCS group than in the LRCS group at 6 and 12 months postoperatively (MD, 2.86; 95% CI 1.38 to 4.35; and MD, 4.19; 95% CI 1.85 to 6.54). RRCS is more favorable than LRCS in preserving the urinary and sexual function of patients with rectal cancer.
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  • 文章类型: Journal Article
    背景:经导管主动脉瓣植入术(TAVI)是严重主动脉瓣狭窄(AS)的高危和中危患者的公认治疗方法。最近的研究表明,与低风险患者的手术相比,TAVI具有非劣效性。在过去的十年里,大量文献综述(SLR)评估了TAVI在不同风险组中的使用情况.这是首次尝试提供SRs(OoSRs)的概述,重点是报告临床结果/过程指标的二级研究。本研究旨在总结现有文献中关于TAVI随时间表现的发现。
    方法:从开始到2024年4月进行了文献检索。我们在MEDLINE和Cochrane图书馆中搜索了SLR。包括报告至少一项临床指标的SLR。随后,进行了两步纳入过程:[1]基于标题和摘要的筛选和[2]基于全文论文的筛选.提取相关数据并评估评论的质量。
    结果:我们纳入了33个通过胸外科医师协会(STS)评分评估不同风险的SLR。TAVI组和外科主动脉瓣置换术(SAVR)组的死亡率相当。TAVI与较低的大出血率有关,急性肾损伤(AKI)发病率,和新发心房颤动。血管并发症,起搏器植入,在TAVI患者中,残余主动脉瓣反流更为常见.
    结论:本研究总结了十年来的TAVI表现发现,揭示了自2020年以来包括高风险和低风险患者的转变。总的来说,TAVI继续发展,强调改进的结果,更广泛的迹象,应对挑战。
    BACKGROUND: Transcatheter aortic valve implantation (TAVI) is a well-established treatment for high and intermediate-risk patients with severe aortic stenosis (AS). Recent studies have demonstrated non-inferiority of TAVI compared to surgery in low-risk patients. In the past decade, numerous literature reviews (SLRs) have assessed the use of TAVI in different risk groups. This is the first attempt to provide an overview of SRs (OoSRs) focusing on secondary studies reporting clinical outcomes/process indicators. This research aims to summarize the findings of extant literature on the performance of TAVI over time.
    METHODS: A literature search took place from inception to April 2024. We searched MEDLINE and the Cochrane Library for SLRs. SLRs reporting at least one review of clinical indicators were included. Subsequently, a two-step inclusion process was conducted: [1] screening based on title and abstracts and [2] screening based on full-text papers. Relevant data were extracted and the quality of the reviews was assessed.
    RESULTS: We included 33 SLRs with different risks assessed via the Society of Thoracic Surgeons (STS) score. Mortality rates were comparable between TAVI and Surgical Aortic Valve Replacement (SAVR) groups. TAVI is associated with lower rates of major bleeding, acute kidney injury (AKI) incidence, and new-onset atrial fibrillation. Vascular complications, pacemaker implantation, and residual aortic regurgitation were more frequent in TAVI patients.
    CONCLUSIONS: This study summarizes TAVI performance findings over a decade, revealing a shift to include both high and low-risk patients since 2020. Overall, TAVI continues to evolve, emphasizing improved outcomes, broader indications, and addressing challenges.
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  • 文章类型: Case Reports
    背景:通过小切口(MT;右前开胸)进行微创心脏手术的发生率正在上升,伴随着MT后肋间神经神经痛的增加和通过切口部位肺疝的风险。虽然已经提出了各种方法来解决这些问题,没有一个是普遍有效的。在这个案例报告中,我们试图通过实施肋间冷冻消融(IC)和网状修复同时解决这些问题.
    方法:一名43岁男性因MT心脏手术后慢性开胸神经痛被转诊到我院,涉及房间隔缺损的补片闭合和三尖瓣成形术。他表现为肋间神经神经痛和肺疝并伴有剧烈疼痛。尽管药物和利多卡因注射,没有解脱。因此,他因慢性MT伤口疼痛接受了IC手术治疗,同时接受了肺疝网片修复术。他出院了,没有并发症。随后,他不再需要进一步的止痛药,并且恢复良好。
    结论:我们的研究结果表明,在接受MT手术的患者中,并发IC和网片修复可以有效缓解慢性MT后肋间神经痛和严重的肺疝疼痛,导致阿片类药物使用减少。
    BACKGROUND: The incidence of minimally invasive heart surgery via mini-thoracotomy (MT; right anterior thoracotomy) is on the rise, accompanied by an increase in post-MT intercostal nerve neuralgia and the risk of lung herniation through the incision site. While various methods have been proposed to address these issues, none have been commonly effective. In this case report, we attempted to simultaneously address these problems by performing intercostal cryoablation (IC) and mesh repair.
    METHODS: A 43-year-old male was referred to our hospital for chronic post-thoracotomy neuralgia following heart surgery via MT, involving patch closure of an atrial septal defect and tricuspid annuloplasty. He presented with intercostal nerve neuralgia and lung herniation accompanied by severe pain. Despite medication and lidocaine injections, there was no relief. Consequently, he underwent surgical treatment with IC for chronic MT wound pain and simultaneously underwent mesh repair for a lung hernia. He was discharged from hospital free of complications. Subsequently, he no longer required further pain medication and experienced a favorable recovery.
    CONCLUSIONS: Our findings suggest that concurrent IC and mesh repair can effectively relieve chronic post-MT intercostal nerve neuralgia and severe lung herniation pain in patients who underwent MT surgery, leading to a decrease in opioid medication usage.
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  • 文章类型: Journal Article
    背景:在这项研究中,我们调查了ABC卒中评分对射频导管消融(RFCA)后阵发性心房颤动(PAF)复发的影响。
    方法:本研究纳入了2018年10月至2019年9月接受RFCA的132例PAF患者。在本研究的第一阶段,根据RFCA后房颤的晚期复发将患者分为两组。在第二阶段,根据ABC卒中评分是否≥6.5,将患者进一步分为两组.
    结果:单因素分析表明PAF晚期复发的危险因素包括早期复发,ABC中风评分,CHA2DS2-VASc评分,NT-proBNP(P<0.05)。Cox多因素回归分析显示,ABC卒中评分(P=0.006)和早期复发(P=0.000)是晚期复发的独立预测因子。ABC卒中评分≥6.5是预测RFCA后PAF复发的风险,其敏感性为66.7%,特异性为65.7%.1:1匹配完成后,单因素Cox分析显示,ABC卒中评分升高(≥6.5)是PAF晚期复发的独立预测因子(HR=2.687,95%CI:1.036~6.971,P=0.042).然而,在6.4时采用ABC卒中评分,预测房性快速性心律失常复发的敏感性为85%,特异性为58.5%.
    结论:ABC卒中评分≥6.4是RFCA后PAF晚期复发的预测因子。
    BACKGROUND: In this study we investigated the impact of ABC stroke score on the recurrence of paroxysmal atrial fibrillation (PAF) following radiofrequency catheter ablation (RFCA).
    METHODS: A total of 132 patients with PAF who underwent RFCA from October 2018 to September 2019 were included in this study. During the first phase of this study the patients were categorized into two groups based on late recurrence of atrial fibrillation after RFCA. In the second phase, the patients were further divided into two groups based on whether their ABC stroke score was ≥ 6.5.
    RESULTS: The univariate analysis indicated that the risk factors for late recurrence of PAF included early recurrence, ABC stroke score, CHA2DS2-VASc score, and NT-proBNP (P < 0.05). Cox multivariate regression analysis revealed that ABC stroke score (P = 0.006) and early recurrence (P = 0.000) were independent predictors of late recurrence, and ABC stroke score ≥ 6.5 was a risk for predicting recurrence of PAF after RFCA with a sensitivity of 66.7% and specificity of 65.7%. After the completion of the 1:1 matching, the univariate Cox analysis indicated that an elevated score of ABC stroke (≥ 6.5) was an independent predictor of late recurrence of PAF (HR = 2.687, 95% CI: 1.036-6.971, P = 0.042). However, using an ABC stroke score cut off at 6.4 predicted the recurrence of atrial tachyarrhythmia with 85% sensitivity and 58.5% specificity.
    CONCLUSIONS: An ABC stroke score ≥ 6.4 is a predictor for late recurrence of PAF after RFCA.
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  • 文章类型: Journal Article
    背景:本手稿旨在描述症状,人口统计,手术方法和技术,手术干预的数量,组织学结果,术中和术后并发症,甲状腺起源的前纵隔肿瘤(AMTTO)患者的术后结果。
    方法:在2017年至2021年间对20例AMTTO患者进行了手术。15人是女性,5人是男性。平均年龄为66.8岁。
    结果:最常见的组织学是结节性小滤泡性和大滤泡性甲状腺肿(15/20,75%)。Kocher宫颈切开术(65%)是首选方法。95%的患者进行了甲状腺全切除术。术中并发症发生率为25%(5/20),2例患者需要气管造口术。术后早期并发症发生率为65%,最常见的是单侧短暂性复发性神经麻痹或瘫痪和发音困难(25%)。
    结论:由于AMTTO与高风险病例相关的复杂性,通常切除AMTTO是一个挑战,强调需要有经验的中心来管理这类案件。
    BACKGROUND: This manuscript aims to describe the symptoms, demographics, surgical approaches and techniques, the volume of surgical interventions, histological results, intra- and postoperative complications, and postoperative results in patients with anterior mediastinal tumors of thyroid origin (AMTTO).
    METHODS: Twenty patients with AMTTO were operated between 2017 and 2021. Fifteen were women and 5 were men. The mean age was 66.8 years.
    RESULTS: The most common histology was nodular micro- and macrofollicular goiter (15/20, 75%). Kocher cervicotomy (65%) was the preferred approach. Total thyroidectomy was performed in 95% of patients. Intraoperative complications were identified in 25% (5/20), and in 2 patients a tracheostomy was required. Early postoperative complications were established in 65% and the most common was unilateral transient recurrent nerve paresis or paralysis and dysphonia (25%).
    CONCLUSIONS: Commonly resection of AMTTO is a challenge due to its complexities associated with high-risk cases, emphasizing the need for experienced centers in managing such cases.
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  • 文章类型: Journal Article
    背景:非心脏手术后的围手术期心肌损伤/梗塞(PMI)是常见的心脏并发症。本研究旨在评估PMI风险,并探索在手术和医疗共同管理(SMC)模型下接受非心脏手术的心血管(CV)风险增加的患者的PMI术前评估工具。
    方法:一项前瞻性队列研究,包括在第二医疗中心接受中高风险非心脏手术的心血管风险增加的连续患者,中国人民解放军总医院,2017年1月至2022年12月。所有患者均接受SMC团队的围手术期处理。SMC模型是在需要手术干预时启动的,贯穿整个围手术期。发病率,危险因素,并分析了PMI对30天死亡率的影响。修订后的心脏风险指数(RCRI)的能力,脆弱,并对它们的组合预测PMI进行了评估。
    结果:613名合格患者(平均值[标准差,SD]年龄73.3[10.9]岁,94.6%男性)连续招募。在SMC下,PMI发生在24/613患者中(3.9%)。PMI患者30天死亡率高于无PMI患者(29.2%vs.0.7%,p=0.00)。虚弱的FRAIL量表与PMI风险增加独立相关(比值比=5.91;95%置信区间[CI],2.34-14.93;p=0.00)。RCRI显示出足够的判别能力来预测PMI(曲线下面积[AUC],0.78;95%CI,0.67-0.88)。将脆弱与RCRI相结合,进一步提高了预测PMI(AUC,0.87;95%CI,0.81-0.93)。
    结论:在SMC下接受中高风险非心脏手术的高CV风险患者中,PMI的发生率相对较低。RCRI充分预测了PMI。将脆弱与RCRI相结合,进一步提高了PMI预测的准确性,实现优秀的歧视能力。这些发现可能有助于对接受中危或高危非心脏手术的高危患者进行个性化评估和管理。
    BACKGROUND: Perioperative myocardial injury/infarction (PMI) following noncardiac surgery is a frequent cardiac complication. This study aims to evaluate PMI risk and explore preoperative assessment tools of PMI in patients at increased cardiovascular (CV) risk who underwent noncardiac surgery under the surgical and medical co-management (SMC) model.
    METHODS: A prospective cohort study that included consecutive patients at increased CV risk who underwent intermediate- or high-risk noncardiac surgery at the Second Medical Center, Chinese PLA General Hospital, between January 2017 and December 2022. All patients were treated with perioperative management by the SMC team. The SMC model was initiated when surgical intervention was indicated and throughout the entire perioperative period. The incidence, risk factors, and impact of PMI on 30-day mortality were analyzed. The ability of the Revised Cardiac Risk Index (RCRI), frailty, and their combination to predict PMI was evaluated.
    RESULTS: 613 eligible patients (mean [standard deviation, SD] age 73.3[10.9] years, 94.6% male) were recruited consecutively. Under SMC, PMI occurred in 24/613 patients (3.9%). Patients with PMI had a higher rate of 30-day mortality than patients without PMI (29.2% vs. 0.7%, p = 0.00). The FRAIL Scale for frailty was independently associated with an increased risk for PMI (odds ratio = 5.91; 95% confidence interval [CI], 2.34-14.93; p = 0.00). The RCRI demonstrated adequate discriminatory capacity for predicting PMI (area under the curve [AUC], 0.78; 95% CI, 0.67-0.88). Combining frailty with the RCRI further increased the accuracy of predicting PMI (AUC, 0.87; 95% CI, 0.81-0.93).
    CONCLUSIONS: The incidence of PMI was relatively low in high CV risk patients undergoing intermediate- or high-risk noncardiac surgery under SMC. The RCRI adequately predicted PMI. Combining frailty with the RCRI further increased the accuracy of PMI predictions, achieving excellent discriminatory capacity. These findings may aid personalized evaluation and management of high-risk patients who undergo intermediate- or high-risk noncardiac surgery.
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